Cardiac Function After Myocardial Ischemia and Reperfusion Inhibition of p38 Mitogen-Activated Protein Kinase Decreases Cardiomyocyte Apoptosis
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چکیده
Xin L. Ma, Sanjay Kumar, Feng Gao, Calvert S. Louden, Bernard L. Lopez, Theodore A. and Improves Cardiac Function After Myocardial Ischemia and Reperfusion Inhibition of p38 Mitogen-Activated Protein Kinase Decreases Cardiomyocyte Apoptosis Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 1999 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.99.13.1685 1999;99:1685-1691 Circulation. http://circ.ahajournals.org/content/99/13/1685 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion.
BACKGROUND Activation of p38 mitogen-activated protein kinase (MAPK) plays an important role in apoptotic cell death. The role of p38 MAPK in myocardial injury caused by ischemia/reperfusion, an extreme stress to the heart, is unknown. METHODS AND RESULTS Studies were performed with isolated, Langendorff-perfused rabbit hearts. Ischemia alone caused a moderate but transient increase in p38 MA...
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AIMS Expression of extracellular matrix protein CCN1 is induced in end-stage ischaemic cardiomyopathy in humans, and after cardiac ischaemia and reperfusion in experimental animal models. Despite its well-documented angiogenic activities, CCN1 increases the cytotoxicities of the tumour necrosis factor family cytokines, which promotes apoptosis in fibroblasts. We aimed to determine the physiolog...
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Oxidative stress participates in numerous myocardial pathophysiological processes and is considered a therapeutic target for myocardial ischemia and heart failure. Guanxintai (GXT), a traditional Chinese medicine, is commonly used to treat cardiovascular disease on account of its numerous beneficial physiological activities, such as dilating coronary arteries, inhibiting platelet aggregation, a...
متن کاملTransforming Growth Factor‐β Receptor III is a Potential Regulator of Ischemia‐Induced Cardiomyocyte Apoptosis
BACKGROUND Myocardial infarction (MI) is often accompanied by cardiomyocyte apoptosis, which decreases heart function and leads to an increased risk of heart failure. The aim of this study was to examine the effects of transforming growth factor-β receptor III (TGFβR3) on cardiomyocyte apoptosis during MI. METHODS AND RESULTS An MI mouse model was established by left anterior descending coron...
متن کاملFR167653 diminishes infarct size in a murine model of myocardial ischemia-reperfusion injury.
OBJECTIVE During myocardial ischemia-reperfusion injury, p38 mitogen-activated protein kinase is activated. We examined the effect of a highly specific inhibitor of p38 mitogen-activated protein kinase, FR167653, in an experimental model of regional myocardial ischemia-reperfusion. METHODS CD-1 mice received FR167653 intraperitoneally 24 hours before 30 minutes of transient occlusion of the l...
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تاریخ انتشار 1999